This briefing note provides a concise and accessible executive summary of the PRI's 2005 Interim Report on cross-border regions which discussed the extensive economic and institutional linkages along the Canada-US border and potential policy implications for the Canadian government. This Briefing Note also presents the results of a survey involving leaders from business, various levels of government, academia, think-tanks, cross-border organizations, and associations on the extent and significance of the emergence of these cross-border regions. (February 2006)