What have universities and other institutions of higher education (HEIs) contributed to the development of regions, in Europe and worldwide, in recent times? What may we expect of the HEIs, and about the development of regions, during the current decade? This follows the global financial crisis – the GFC - in a context of continuing ecological stress and continuing environmental degradation. What part do leading intergovernmental organisations play in all of this – and how about relations between Europe and other parts of a rapidly changing world?