The loss of any major employer from a region, especially a relatively (in South East UK terms) isolated and deprived one, is devastating. However, the loss of research and development and extremely high-value knowledge workers may have an irreversable impact on the economy and social fabric as a whole.
This is the case for East Kent, the South East of England's most deprived area, as this week Pfizer announced that it would be closing their facility near Sandwich with the loss of 2,400 R&D jobs.